Cannabinoides y su nanoencapsulamiento para mejorar sus propiedades terapéuticas en padecimientos intestinales
Keywords:
phytocannabinoids, cannabis, endocannabinoidome, nanotechnology, nanoparticlesAbstract
The cannabis plant has generated interest and controversy due to its diverse uses, among which medicinal uses stand out. Cultivated for thousands of years and distributed globally, this plant produces various substances of medicinal interest, such as phytocannabinoids, which interact with the endocannabinoid system (ECS) and the endocannabinoidome (eCBoma) in animals. These systems are active in healthy individuals and various pathologies, playing crucial roles in intestinal homeostasis and condition inflammatory processes. Therapeutic cannabinoids, known for their anti-inflammatory properties, face several limitations, such as low solubility and bioavailability by some routes of administration, as well as being vulnerable to environmental and physiological factors. Nanotechnology emerges as a promising solution to overcome these obstacles in herbal medicine. Various methodologies have been developed to create nano-delivery systems, such as polymeric nanoparticles, enhancing the physicochemical properties and therapeutic potential of cannabinoids. Advances in nanoencapsulation have shown positive results, enhancing the effectiveness of phytocannabinoids in medical applications.
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