Cannabis and Inflammatory Bowel Disease: An Exploration of the Medicinal Potential
DOI:
https://doi.org/10.29105/agricolis.v1i3.23Keywords:
colitis, gastrointestinal, endocannabinoid, endocannabinoid systemAbstract
Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract. They occur in both humans and other animals and their prevalence varies globally. Although their exact etiology remains uncertain, it is accepted that they result from a complex interaction between the immune system, intestinal microbiota, genetic susceptibility and environmental factors. Conventional pharmacological treatment does not ensure long-term benefits. Recently, the use of natural plant compounds, such as cannabinoids from cannabis (Cannabis sativa L.), have been investigated as potential therapeutic agents for IBD. Phytocannabinoids interact with the endocannabinoidome, which plays a crucial role in gastrointestinal health and in modulating pathological processes such as chronic inflammation. In the present work we will address the characteristics of IBD, the cannabis plant, its therapeutic potential and its history of medicinal use by mankind.
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References
Barcaccia, G., Palumbo, F., Scariolo, F., Vannozzi, A., Borin, M., Bona, S., 2020. Potentials and Challenges of Genomics for Breeding Cannabis Cultivars. Front. Plant Sci. 11. https://doi.org/10.3389/fpls.2020.573299
Brierley, D.I., Samuels, J., Duncan, M., Whalley, B.J., Williams, C.M., 2016. Cannabigerol is a novel, well-tolerated appe-tite stimulant in pre-satiated rats. Psychopharmacology (Berl). 233, 3603–3613. https://doi.org/10.1007/s00213-016-4397-4
Busquets-García, A., Bolaños, J.P., Marsicano, G., 2022. Metabolic Messengers: endocannabinoids. Nat. Metab. 4, 848–855. https://doi.org/10.1038/s42255-022-00600-1
Citti, C., Linciano, P., Russo, F., Luongo, L., Iannotta, M., Maione, S., Laganà, A., Capriotti, A.L., Forni, F., Vandelli, M.A., Gigli, G., Cannazza, G., 2019. A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimi-metic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol. Sci. Rep. 9, 20335. https://doi.org/10.1038/s41598-019-56785-1
Couch, D.G., Maudslay, H., Doleman, B., Lund, J.N., O’Sullivan, S.E., 2018. The Use of Cannabinoids in Colitis: A Sys-tematic Review and Meta-Analysis. Inflamm. Bowel Dis. 24, 680–697. https://doi.org/10.1093/ibd/izy014
de Mattos, B.R.R., Garcia, M.P.G., Nogueira, J.B., Paiatto, L.N., Albuquerque, C.G., Souza, C.L., Fernandes, L.G.R., Tama-shiro, W.M.D.S.C., Simioni, P.U., 2015. Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biolog-ical Treatments. Mediators Inflamm. 2015, 1–11. https://doi.org/10.1155/2015/493012
Di Marzo, V., Piscitelli, F., 2015. The Endocannabinoid System and its Modulation by Phytocannabinoids. Neurothera-peutics 12, 692–698. https://doi.org/10.1007/s13311-015-0374-6
ElSohly, M.A., Radwan, M.M., Gul, W., Chandra, S., Galal, A., 2017. Phytochemistry of Cannabis sativa L., in: Phyto-cannabinoids: Unraveling the Complex Chemistry and Pharmacology of Cannabis Sativa. Progress in the Chemistry of Organic Natural Products, Cham, pp. 1–36. https://doi.org/10.1007/978-3-319-45541-9_1
Eltantawy, N., El-Zayyadi, I.A.E.H., Elberry, A.A., Salah, L.M., Abdelrahim, M.E.A., Kassem, A.B., 2023. A review article of inflammatory bowel disease treatment and pharmacogenomics. Beni-Suef Univ. J. Basic Appl. Sci. 12. https://doi.org/10.1186/s43088-023-00361-0
Farag, S., Kayser, O., 2017. The Cannabis Plant: Botanical Aspects, in: Press, A. (Ed.), Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier, London, pp. 3–12. https://doi.org/10.1016/B978-0-12-800756-3.00001-6
Fernández-Ruiz, J., Romero, J., Ramos, J.A., 2015. Endocannabinoids and Neurodegenerative Disorders: Parkinson’s Disease, Huntington’s Chorea, Alzheimer’s Disease, and Others, in: Pertwee, R.G. (Ed.), Endocannabinoids, Handbook of Experimental Pharmacology. Springer International Publishing, Cham, pp. 233–259. https://doi.org/10.1007/978-3-319-20825-1_8
Guo, B., Bian, Z., Qiu, H., Wang, Yi-tao, Wang, Ying, 2017. Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease 37–48. https://doi.org/https://doi.org/10.1111/nyas.13414
Hartsel, J.A., Boyar, K., Pham, A., Silver, R.J., Makriyannis, A., 2019. Cannabis in Veterinary Medicine: Cannabinoid Therapies for Animals, in: Nutraceuticals in Veterinary Medicine. Springer International Publishing, Cham, pp. 121–155. https://doi.org/10.1007/978-3-030-04624-8_10
Hourfane, S., Mechqoq, H., Bekkali, A.Y., Rocha, J.M., El Aouad, N., 2023. A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities. Plants 12, 1–43. https://doi.org/10.3390/plants12061245
Iffland, K., Grotenhermen, F., 2017. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2, 139–154. https://doi.org/10.1089/can.2016.0034
Ishiguro, H., 2023. Editorial: Targeting the endocannabinoidome in neurodegenerative disorders. Front. Aging Neurosci. 14. https://doi.org/10.3389/fnagi.2022.1116635
Jergens, A.E., Simpson, K.W., 2012. Inflammatory bowel disease in veterinary medicine. Front. Biosci. - Elit. 4 E, 1404–1419. https://doi.org/10.2741/e470
Kicman, A., Toczek, M., 2020. The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascu-lar system in health and disease, International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21186740
Klumpers, L.E., Thacker, D.L., 2019. A brief background on cannabis: From plant to medical indications. J. AOAC Int. 102, 412–420. https://doi.org/10.5740/jaoacint.18-0208
Lu, Q., Yang, M.F., Liang, Y.J., Xu, J., Xu, H.M., Nie, Y.Q., Wang, L.S., Yao, J., Li, D.F., 2022. Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics. J. Inflamm. Res. 15, 1825–1844. https://doi.org/10.2147/JIR.S353038
Malik, T.A., 2015. Inflammatory Bowel Disease. Historical Perspective, Epidemiology, and Risk Factors. Surg. Clin. North Am. https://doi.org/10.1016/j.suc.2015.07.006
Martínez, V., Iriondo De-Hond, A., Borrelli, F., Capasso, R., Del Castillo, M.D., Abalo, R., 2020. Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: Useful nutraceuticals? Int. J. Mol. Sci. 21. https://doi.org/10.3390/ijms21093067
Naftali, T., Mechulam, R., Lev, L.B., Konikoff, F.M., 2014. Cannabis for Inflammatory Bowel Disease. Dig. Dis. 32, 468–474. https://doi.org/10.1159/000358155
Nduma, B.N., Mofor, K.A., Tatang, J., Ekhator, C., Ambe, S., Fonkem, E., 2023. The Use of Cannabinoids in the Treatment of Inflammatory Bowel Disease (IBD): A Review of the Literature. Cureus 15. https://doi.org/10.7759/cureus.36148
Ramos-Guerrero, L., Montalvo, G., Cosmi, M., García-Ruiz, C., Ortega-Ojeda, F.E., 2022. Classification of Various Mari-juana Varieties by Raman Microscopy and Chemometrics. Toxics 10, 115. https://doi.org/10.3390/toxics10030115
Russo, E.B., 2015. The Pharmacological History of Cannabis, in: Handbook of Cannabis. https://doi.org/10.1093/acprof:oso/9780199662685.003.0002
Saez, A., Herrero-Fernandez, B., Gomez-Bris, R., Sánchez-Martinez, H., Gonzalez-Granado, J.M., 2023. Pathophysiology of Inflammatory Bowel Disease: Innate Immune System. Int. J. Mol. Sci. 24. https://doi.org/10.3390/ijms24021526
Sałaga, M., Abalo, R., Fichna, J., 2017. Chapter 49. the Effects on Gastrointestinal Function : An Overview, Handbook of Cannabis and Related Pathologies. Elsevier Inc. https://doi.org/10.1016/B978-0-12-800756-3/00056-9
Seyedian, S.S., Nokhostin, F., Malamir, M.D., 2019. A review of the diagnosis, prevention, and treatment methods of in-flammatory bowel disease. J. Med. Life 12, 113–122. https://doi.org/10.25122/jml-2018-0075
Shah, S.C., Itzkowitz, S.H., 2022. Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management. Gastroenterology 162, 715-730.e3. https://doi.org/10.1053/j.gastro.2021.10.035
Toczek, M., Malinowska, B., 2018. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life Sci. 204, 20–45. https://doi.org/10.1016/j.lfs.2018.04.054
Turner, S.E., Williams, C.M., Iversen, L., Whalley, B.J., 2017. Molecular Pharmacology of Phytocannabinoids, Spanier. ed, Progress in the chemistry of organic natural products. Progress in the Chemistry of Organic Natural Products, Cham. https://doi.org/10.1007/978-3-319-45541-9_3
Yamamoto-Furusho, J.K., Bosques-Padilla, F., de-Paula, J., Galiano, M.T., Ibañez, P., Juliao, F., Kotze, P.G., Rocha, J.L., Steinwurz, F., Veitia, G., Zaltman, C., 2017. Diagnosis and treatment of inflammatory bowel disease: First Latin Ameri-can Consensus of the Pan American Crohn’s and Colitis Organisation. Rev. Gastroenterol. México (English Ed. 82, 46–84. https://doi.org/10.1016/j.rgmxen.2016.07.003
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Copyright (c) 2024 MCA. Kevin Antonio, Jesica Torres Covarrubias, ADOLFO Soto Domínguez, RAYMUNDO ALEJANDRO, Dr. Miguel Ángel, Gustavo, Aime Jazmin., Uziel Castillo
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